| MSX 2 cart. |  Dragon Quest II - Akuryou no Kamigami Model E-G207 P | 1988 | Enix, Ltd. Japan |
| MSX 2 cart. | Dragon Quest Model E-G184 | 1986 | Enix, Ltd. Japan |
| MSX 2 cart. | Dragon Slayer IV - Drasle Family Model MXNW12001 P | 1987 | Falcom Japan |
| MSX 2 cart. | Druid Model ND-08MR | 1988 | Nihon Dexter Japan |
| MSX 2 cart. | Dynamite Bowl Model PS-2021G | 1987 | Toshiba EMI Japan |
| MSX 2 cart. | Elthlead Model MXNC22001 | 1988 | NCS Corp. Nippon Computer Systems Japan |
| MSX 2 cart. | Europa Sensen Model KN10221050 P | 1992 | KOEI Co., Ltd. Japan |
| MSX 2 cart. | F-15 Strike Eagle | 1987 | SystemSoft Corp. Japan |
| MSX 2 cart. | Famicle Parodic | 1988 | Bit2 Japan |
| MSX 2 cart. | Family Billiards Model MS-14 | 1987 | Pack-In-Video Co., Ltd. Japan |
| MSX 2 cart. | Family Boxing Model HBS-G066C | 1988 | Sony Corp. Japan |
| MSX 2 cart. | Fantasy Zone II - The Tears of Opa-Opa Model R68Y5815 | 1987 | Pony Canyon, Inc. Japan |
| MSX 2 cart. | Feedback | 1988 | Tecno Soft. TechnoSoft Japan |
| MSX 2 cart. | Fireball Model 12421 | 1987 | HummingBird Japan |
| MSX 2 cart. | Fleet Commander II - Tasogare no Kaiiki | 1990 | ASCII Corp. Japan |
| MSX 2 cart. | Gakuen Monogatari - High School Story | 1988 | Great Japan |
| MSX 2 cart. | Gambler Jikochuushinha 2 - Jishou! Kyougou Janshi-hen | 1988 | Game Arts Co., Ltd. Japan |
| MSX 2 cart. | Ganbare Goemon! Karakuri Douchuu Model RC748 P | 1987 | Konami Industry Co., Ltd. Japan |
| MSX 2 cart. | Garakuta | 1988 | Wachi Soft. |
| MSX 2 cart. | Garyuu Ou Model MXZS-12004 | 1987 | Xain Soft. Japan |
| MSX 2 cart. | Gekitotsu Pennant Race 2 Model RC766 | 1989 | Konami Industry Co., Ltd. Japan |
| MSX 2 cart. | Gekitotsu! Pennant Race - The Pro Yakyuu Model RC757 | 1988 | Konami Industry Co., Ltd. Japan |
| MSX 2 cart. | Girly Block Model NGS-001 | 1988 | Telenet Japan |
| MSX 2 cart. | Gogoboom Hb | 2022 | ESP Soft. |
| MSX 2 cart. | Gold Fan Hb | 2016 | NI |
| MSX 2 cart. | Hacker | 1988 | Pony Canyon, Inc. Japan |
| MSX 2 cart. | Hai no Majutsushi Model RC765 | 1989 | Konami Industry Co., Ltd. Japan |
| MSX 2 cart. | Han Seimei Senki Androgynus | 1988 | Telenet Japan |
| MSX 2 cart. | Hardball Model HBS-G060C | 1987 | Sony Corp. Japan |
| MSX 2 cart. | Hi no Tori - Houou-hen Model RC747 | 1987 | Konami Industry Co., Ltd. Japan |
| MSX 2 cart. | Higemaru Makaijima - Nanatsu no Shima Daibouken Model CAP-201 | 1987 | Capcom Co., Ltd. Japan |
| MSX 2 cart. | High School! Kimengumi Model R58Y5813 | 1987 | Pony Canyon, Inc. Japan |
| MSX 2 cart. | Hole in One Special Model HM-022 | 1987 | HAL Laboratory, Inc. Japan |
| MSX 2 cart. |  Hydlide 3 - The Space Memories | 2006 | Bazix |
| MSX 2 cart. | Hydlide 3 - The Space Memories Model TEX-80 P | 1987 | T&E Soft. Japan |
| MSX 2 cart. | Hydlide Bronze Pack | 1987 | T&E Soft. Japan |
| MSX 2 cart. | Ide Yousuke Meijin no Jissen Mahjong Model MS-18 | 1988 | Pack-In-Video Co., Ltd. Japan |
| MSX 2 cart. | Ikari Model SFX-IK P | 1987 | SNK Corp. Shin Nihon Kikaku Japan |
| MSX 2 cart. | Inemuri-ryuu Asada Tetsuya no A-kyuu Mahjong | 1988 | Pony Canyon, Inc. Japan |
| MSX 2 cart. | Inindou - Datou Nobunaga with Soundware | 199? | KOEI Co., Ltd. Japan |
