| MSX 2 cart. |  Inindou - Datou Nobunaga Model KN10181050 | 1991 | KOEI Co., Ltd. Japan |
| MSX 2 cart. | Ishin no Arashi Model MXKN12017 | 1989 | KOEI Co., Ltd. Japan |
| MSX 2 cart. | J.B. Harold Jikenbo #1: Final Mystery - Murder Club | 1988 | Micro Cabin Co. Japan |
| MSX 2 cart. | Jailbreak Hb | 2010 | Infinite |
| MSX 2 cart. | Jansei | 1986 | Sony Corp. Japan |
| MSX 2 cart. | Junior Mate Model PANA-092 | 1987 | Panasoft |
| MSX 2 cart. | Kempelen Chess Model R55Y-5152 | 1988 | Pony Canyon, Inc. Japan |
| MSX 2 cart. | Kiki KaiKai Model HBS-G063C P | 1987 | Sony Corp. Japan |
| MSX 2 cart. | King Kong 2 - Yomigaeru Densetsu | 1987 | Zemina Korea |
| MSX 2 cart. | King Kong 2 - Yomigaeru Densetsu Model RC745 | 1986 | Konami Industry Co., Ltd. Japan |
| MSX 2 cart. | Kisei - Honkaku Shogi Soft Model HBS-G057C | 1987 | Sony Corp. Japan |
| MSX 2 cart. | Kitahei Model MIC-M022R | 1986 | Micro Cabin Co. Japan |
| MSX 2 cart. | Knight Lore Remake Hb | 2009 | RetroWorks |
| MSX 2 cart. | Koronis Rift Model R68Y-5516 | 1987 | Pony Canyon, Inc. Japan |
| MSX 2 cart. | L'Empereur Model KN10021070 | 1990 | KOEI Co., Ltd. Japan |
| MSX 2 cart. | L'Empereur Model KN10031050 | 1991 | KOEI Co., Ltd. Japan |
| MSX 2 cart. | Labyrinth | 1987 | Pack-In-Video Co., Ltd. Japan |
| MSX 2 cart. | Los Amores de Brunilda Hb | 2019 | RetroWorks |
| MSX 2 cart. | Lupin Sansei - Babylon no Ougon Densetsu | 1988 | Toho Co., Ltd. Japan |
| MSX 2 cart. | Lupin Sansei - Cagliostro no Shiro Model CS11-008R | 1987 | Toho Co., Ltd. Japan |
| MSX 2 cart. | Mad Rider | 1987 | Carry Lab. Japan |
| MSX 2 cart. | Maison Ikkoku | 1987 | Micro Cabin Co. Japan |
| MSX 2 cart. | Maison Ikkoku Kanketsu-Hen - Sayonara Soshite... Model 82580 | 1988 | Micro Cabin Co. Japan |
| MSX 2 cart. | Malaya no Hihou Model R58Y-5115 | 1988 | Pony Canyon, Inc. Japan |
| MSX 2 cart. | Manbow 2 Hb | 2007 | Sunrise |
| MSX 2 cart. | Metal Gear 2 - Solid Snake Model RC767 | 1990 | Konami Industry Co., Ltd. Japan |
| MSX 2 cart. | Metal Gear Model RC750 | 1987 | Konami Industry Co., Ltd. Japan |
| MSX 2 cart. | Mirae Sonyeon Conan | 1989 | Topia Korea |
| MSX 2 cart. | Mirai Model MXZS-12002 | 1987 | Xain Soft. Japan |
| MSX 2 cart. | Mississippi Satsujin Jiken Model JX-15 | 1987 | JALECO Co., Ltd. Japan |
| MSX 2 cart. | Moero! Nettou Yakyuu '88 | 1988 | JALECO Co., Ltd. Japan |
| MSX 2 cart. | Mole Mole Model M-2001 | 1986 | Cross Media Soft Japan |
| MSX 2 cart. | Mon Mon Monster | 1989 | Hot-B Japan |
| MSX 2 cart. | Moskow 2024 | 2014 | Matra Computer Automations Spain |
| MSX 2 cart. | Nekketsu Juudou | 1989 | Pony Canyon, Inc. Japan |
| MSX 2 cart. | Ninja-Kun - Ashura no Shou Model HM-028 | 1987 | HAL Laboratory, Inc. Japan |
| MSX 2 cart. | No Ren-Sha Hb | 2016 | Ochixn |
| MSX 2 cart. | Nobunaga no Yabou - Bushou Fuuunroku Model KN10111040 | 1991 | KOEI Co., Ltd. Japan |
| MSX 2 cart. | Nobunaga no Yabou - Bushou Fuuunroku Model KN10121040 | 1991 | KOEI Co., Ltd. Japan |
| MSX 2 cart. | Nobunaga no Yabou - Sengoku Gunyuuden Model MXKN12009 | 1989 | KOEI Co., Ltd. Japan |
