| NEC PC-9801 Series 5.25in. disk |  Engage Errands | 1993 | PonyTail Soft |
| NEC PC-9801 Series 5.25in. disk | Engage Errands II - Hikari o Ninau Mono | 1995 | PonyTail Soft |
| NEC PC-9801 Series 5.25in. disk | Entführer - Yousei Yuukai Jiken | 1989 | Zenryutsu Japan |
| NEC PC-9801 Series 5.25in. disk | Epic | 1992 | Imagineer Co., Ltd. Japan |
| NEC PC-9801 Series 5.25in. disk | Es no Houteishiki 18 | 1996 | Abogado Powers |
| NEC PC-9801 Series 5.25in. disk | Escalation '95 - Oneesama tte Yonde Ii Desu ka? 18 | 1995 | Fairy Dust Japan |
| NEC PC-9801 Series 5.25in. disk | Escape! 18 | 1996 | May-Be Soft. Japan |
| NEC PC-9801 Series 5.25in. disk | Estate | 1995 | Lip Star Japan |
| NEC PC-9801 Series 5.25in. disk | Estoria | 1993 | Soft Plan Co., Ltd. Japan |
| NEC PC-9801 Series 5.25in. disk | Etemible - Tenjou Mukyuu | 1995 | Glodia Co., Ltd. Japan |
| NEC PC-9801 Series 5.25in. disk | Eteris | 199? | Unknown Japan |
| NEC PC-9801 Series 5.25in. disk | Etsuraku no Gakuen 18 | 1994 | C's Ware |
| NEC PC-9801 Series 5.25in. disk | Europa Sensen Model KN10221020 P | 1992 | KOEI Co., Ltd. Japan |
| NEC PC-9801 Series 5.25in. disk | EVE - Burst Error Model OR-9772 18 | 1995 | C's Ware |
| NEC PC-9801 Series 5.25in. disk | Ex-Lander - Aoki Monshou no Kishidan | 1993 | Micro Vision |
| NEC PC-9801 Series 5.25in. disk | Exciting Wild Flowers | 199? | Unknown Japan |
| NEC PC-9801 Series 5.25in. disk | Executioners | 1993 | Softec Japan |
| NEC PC-9801 Series 5.25in. disk | Executive e no Michi | 1987 | Champion Soft. Japan |
| NEC PC-9801 Series 5.25in. disk | Exodus - Ultima III | 1985 | Starcraft, Inc. Japan |
| NEC PC-9801 Series 5.25in. disk | eXOn | 1991 | Softec Japan |
| NEC PC-9801 Series 5.25in. disk |  eXOn Demo | 1991 | Softec Japan |
| NEC PC-9801 Series 5.25in. disk | Exterlien 18 | 1990 | DO Corp. Japan |
| NEC PC-9801 Series 5.25in. disk | F-1 Databox | 199? | Unknown Japan |
| NEC PC-9801 Series 5.25in. disk | F-117A Nighthawk - Stealth Fighter 2.0 | 1994 | MicroProse Japan K.K. |
| NEC PC-9801 Series 5.25in. disk | F-14 Fleet Defender | 1995 | MicroProse Japan K.K. |
| NEC PC-9801 Series 5.25in. disk | F-15 Strike Eagle | 1988 | SystemSoft Corp. Japan |
| NEC PC-9801 Series 5.25in. disk | F-15 Strike Eagle II | 1990 | MicroProse Japan K.K. |
| NEC PC-9801 Series 5.25in. disk | F-15 Strike Eagle II 256 | 1993 | MicroProse Japan K.K. |
| NEC PC-9801 Series 5.25in. disk | F-16 Fighting Falcon 2 | 1988 | ASCII Corp. Japan |
| NEC PC-9801 Series 5.25in. disk | F-19 Stealth Fighter Special Model MP40611010 | 1992 | MicroProse Japan K.K. |
| NEC PC-9801 Series 5.25in. disk | F1 GP Championship | 1995 | Bio 100% Japan |
| NEC PC-9801 Series 5.25in. disk | F29 Retaliator | 1992 | Imagineer Co., Ltd. Japan |
| NEC PC-9801 Series 5.25in. disk | Fairie's Residence Model NFCP-14007 | 1986 | Champion Soft. Japan |
| NEC PC-9801 Series 5.25in. disk | Fairy Angel 18 | 1995 | Software Circle Courreges Japan |
| NEC PC-9801 Series 5.25in. disk | Fairytale 18 | 1987 | Fairytale Japan |
| NEC PC-9801 Series 5.25in. disk | Fairytale Kaizokuban | 1991 | Fairytale Japan |
| NEC PC-9801 Series 5.25in. disk | Faladia | 1994 | Sofcom Japan |
| NEC PC-9801 Series 5.25in. disk | Falcom Character CG | 1990 | Takeru Co. Ltd Japan |
| NEC PC-9801 Series 5.25in. disk | Fall | 1991 | Queensoft Japan |
| NEC PC-9801 Series 5.25in. disk | Falla no Jikekkai | 1991 | Heart Soft. Japan |
