| Apple Macintosh CD |  Roberta Williams' Phantasmagoria | 1995 | Sierra On-Line, Inc. USA 20626 |
| Apple Macintosh CD | Sim City 2000 - Special Edition | 1994 | Maxis Soft. Moraga, CA, USA |
| Apple Macintosh CD | SimCity - Enhanced CD-ROM P | 1995 | MacPlay CA, USA |
| Apple Macintosh CD | SimCity 3000 | 1999 | Maxis Soft. Moraga, CA, USA |
| Apple Macintosh CD | SimCity 4 P | 2003 | Aspyr |
| Apple Macintosh CD | SimCity 4 - Deluxe Edition P | 2005 | Aspyr |
| Apple Macintosh CD | SimCity Deluxe & Earth | 199? | Imagineer Co., Ltd. Japan |
| Apple Macintosh CD | SimPeople Model EAM-7020 | 200? | Unknown |
| Apple Macintosh CD | SimTown - The Town You Build Yourself! | 1995 | Maxis Soft. Moraga, CA, USA |
| Apple Macintosh CD | Sinkha | 1996 | Virtual Views |
| Apple Macintosh CD | Solitaire Mania | 1996 | Semicolon Soft. |
| Apple Macintosh CD | Sotsugyou - Graduation | 1994 | Emotional Digital Soft. |
| Apple Macintosh CD | Space Adventure | 1994 | Knowledge Adventure, Inc. |
| Apple Macintosh CD | Space Quest 6 - Roger Wilco in the Spinal Frontier P | 1996 | Sierra On-Line, Inc. USA 20626 |
| Apple Macintosh CD | Space Shuttle | 1993 | Software Toolworks, The |
| Apple Macintosh CD | Spider-Man - The Movie P | 2002 | Aspyr |
| Apple Macintosh CD | Spycraft - The Great Game | 1996 | Activision, Inc. Los Angeles, CA, USA 47875 |
| Apple Macintosh CD | Star Fighter | 1996 | 3DO Co., The CA, USA |
| Apple Macintosh CD | Star Trek - Elite Force II | 2003 | Aspyr |
| Apple Macintosh CD | Star Trek - Starfleet Academy | 1997 | Interplay |
| Apple Macintosh CD | Star Trek - The Next Generation - Klingon Honor Guard | 1999 | MacSoft |
| Apple Macintosh CD | Star Trek Voyager - Elite Force | 2000 | Aspyr |
| Apple Macintosh CD | Star Wars - Battlefront P | 2005 | Aspyr |
| Apple Macintosh CD | Star Wars - Dark Forces Model 30621 | 1995 | LucasArts Ent. Co. |
| Apple Macintosh CD | Star Wars - Jedi Knight - Jedi Academy | 2003 | Aspyr |
| Apple Macintosh CD | Star Wars - Jedi Knight II - Jedi Outcast | 2002 | Aspyr |
| Apple Macintosh CD | Star Wars - Knights of the Old Republic | 2004 | Aspyr |
| Apple Macintosh CD | Star Wars - Rebel Assault Model 30421 | 1993 | LucasArts Ent. Co. |
| Apple Macintosh CD |  Star Wars - The Force Unleashed - Ultimate Sith Edition | 2010 | Aspyr |
| Apple Macintosh CD | Star Wars - TIE Fighter - Collector's CD-ROM | 1997 | LucasArts Ent. Co. |
| Apple Macintosh CD | Star Wars - X-Wing - Collector's CD-ROM Model 20521 | 1996 | LucasArts Ent. Co. |
| Apple Macintosh CD | Star Wars Episode I - Racer Model 65321 | 2000 | LucasArts Ent. Co. |
| Apple Macintosh CD | Star Wars: Rebel Assault II - The Hidden Empire Model 30921 | 1995 | LucasArts Ent. Co. |
| Apple Macintosh CD | StarCraft P | 1999 | Blizzard Ent., Inc. |
| Apple Macintosh CD | StarCraft - Brood War P | 1999 | Blizzard Ent., Inc. |
| Apple Macintosh CD | Stellaluna | 1996 | Broderbund Soft., Inc. CA, USA 47956 |
| Apple Macintosh CD | Stubbs the Zombie in Rebel Without a Pulse | 2005 | Aspyr |
| Apple Macintosh CD | System Shock P | 1995 | Origin Systems, Inc. An Electronic Arts Co. 17814 |
| Apple Macintosh CD | Terry Pratchett's Discworld | 1995 | Psygnosis, Ltd. |
| Apple Macintosh CD | The 11th Hour Model 83020 | 1997 | Virgin Interactive Ent., Ltd. UK 013715 |
