| Sega Mega Drive cart. |  Kidou Keisatsu Patlabor - 98-shiki Kidou Seyo! Model T-16013 | 1992 | Ma-Ba |
| Sega Mega Drive cart. | King of the Monsters Model G-4104 | 1993 | Takara Co., Ltd. Japan |
| Sega Mega Drive cart. | King Salmon | 1992 | Hot-B Japan |
| Sega Mega Drive cart. |  King's Bounty - The Conqueror's Bounty | 1991 | Electronic Arts CA, USA 14633 |
| Sega Mega Drive cart. | Kishi Densetsu Model T-46033 | 1993 | Kodansha Japan |
| Sega Mega Drive cart. | Klax | 1990 | Tec Toy Industria de Brinquedos S.A. Brazil |
| Sega Mega Drive cart. | Klax Model 301040-0170 | 1990 | Tengen, Inc. Milpilas, CA, USA |
| Sega Mega Drive cart. | Klax Model T-14063 | 1990 | NAMCOT Japan |
| Sega Mega Drive cart. |  Knuckles in Sonic 2 | 1994 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Kolobok - Pyramid | 199? | Unknown |
| Sega Mega Drive cart. | Koutetsu Teikoku Model T-28033 | 1992 | Hot-B Japan |
| Sega Mega Drive cart. | Krusty's Super Fun House Model T-81036-50 | 1992 | Flying Edge |
| Sega Mega Drive cart. | Kuhga - Operation Code Vapor Trail Model T-49043 | 1991 | Telenet Japan |
| Sega Mega Drive cart. | Kujaku Ou 2 - Geneijou Model G-4017 | 1989 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Kuzya - Ekologiya V Opasnosti | 199? | Unknown |
| Sega Mega Drive cart. | Kuzya - V Mire Dinozavrov | 199? | Unknown |
| Sega Mega Drive cart. | Kyuukai Douchuuki Model T-14103 | 1991 | NAMCOT Japan |
| Sega Mega Drive cart. | Kyuukyoku Tiger Model T-24033 | 1991 | TRECO |
| Sega Mega Drive cart. | L'Abbaye des Morts Model POR 002 P Hb | 2017 | PlayOnRetro |
| Sega Mega Drive cart. | La Légende de Thor Model 1354-09 | 1995 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Landstalker - Die Schätze von König Nolo Model 1353-18 | 1993 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Landstalker - Koutei no Zaihou Model G-5517-11 | 1992 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Landstalker - Koutei no Zaihou Model G-5517 | 1992 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Landstalker - Le Trésor du Roi Nole Model 1353-09 | 1993 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Landstalker - The Treasures of King Nole Model 1353-03 | 1993 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Landstalker 2 - Heart of Diamond | 1997 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Landstalker Model 046140 | 1993 | Tec Toy Industria de Brinquedos S.A. Brazil |
| Sega Mega Drive cart. | Langrisser II Model T-25143 | 1994 | NCS Corp. Nippon Computer Systems Japan |
| Sega Mega Drive cart. | Langrisser Model T-25103 | 1991 | NCS Corp. Nippon Computer Systems Japan |
| Sega Mega Drive cart. | LaSalle Ishii no Quiz! Kyoiku Iinkai | 199? | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Last Battle | 1990 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Lemmings | 1992 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Lemmings 2 - The Tribes | 1994 | Psygnosis, Ltd. |
| Sega Mega Drive cart. | Lemmings Model T-15063 | 1992 | SUNSOFT Kounan, Japan |
| Sega Mega Drive cart. | Lethal Enforcers II - Gun Fighters Model T-95136-50 | 1994 | Konami Co., Ltd. Japan |
| Sega Mega Drive cart. | Lethal Enforcers Model T-95073 P | 1993 | Konami Co., Ltd. Japan |
| Sega Mega Drive cart. | Lethal Enforcers Model T-95096-50 | 1993 | Konami Co., Ltd. Japan |
| Sega Mega Drive cart. | LHX Attack Chopper | 1993 | Electronic Arts CA, USA 14633 |
| Sega Mega Drive cart. | Light Crusader Model 1187-50 | 1995 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Light Crusader Model FLIG04SMC | 199? | SEGA OziSoft Australia |
