| Sega Mega Drive cart. |  Light Crusader Model G-5545 | 1995 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Light Crusader Model GM95004JT | 1995 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Ling Huan Dao Shi - Super Magician Model GM-95402 | 199? | Ming China |
| Sega Mega Drive cart. | Link Dragon | 1993 | Songtly |
| Sega Mega Drive cart. | Lord Monarch - Tokoton Sentou Densetsu Model G-5534 | 1994 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Lord of the Rings | 199? | Unknown |
| Sega Mega Drive cart. | Ma Jiang Qing Ren - Ji Ma Jiang Zhi | 199? | Unknown |
| Sega Mega Drive cart. | Ma Qiao E Mo Ta - Devilish Mahjong Tower Model G-3031 | 1994 | C&E Computer & Ent., Inc. Taiwan |
| Sega Mega Drive cart. | Mad Stalker - Full Metal Forth | 2020 | Columbus Circle Japan |
| Sega Mega Drive cart. | Madagascar - Operatsiya Pingvin | 199? | Unknown |
| Sega Mega Drive cart. | Madagascar 3 | 2008 | Unknown Russia |
| Sega Mega Drive cart. | Madou Monogatari I Model T-66023 | 1996 | Compile |
| Sega Mega Drive cart. | Mafia | 199? | Unknown |
| Sega Mega Drive cart. | Magic Bubble Model G-3011 | 1993 | C&E Computer & Ent., Inc. Taiwan |
| Sega Mega Drive cart. | Magical Hat no Buttobi Tabo! Daibouken Model G-4041 | 1990 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Magical Taruruuto-kun Model G-4068 | 1992 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Magistr 16 | 199? | Unknown |
| Sega Mega Drive cart. | Mahjong Cop Ryuu - Shiro Ookami no Yabou | 1989 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Mamono Hunter Youko - Dai 7 no Keishou | 1991 | NCS Corp. Nippon Computer Systems Japan |
| Sega Mega Drive cart. | Maou Renjishi Model T-11143 | 1991 | Taito Corp. Japan |
| Sega Mega Drive cart. |  Marble Madness Model E004SMXI P | 1993 | Electronic Arts CA, USA 14633 |
| Sega Mega Drive cart. | Marble Madness Model T-48113 | 1993 | Tengen, Inc. Milpilas, CA, USA |
| Sega Mega Drive cart. | Marko's Magic Football | 1994 | Domark Group, Ltd. |
| Sega Mega Drive cart. | Marko's Magic Football Model FMAR04SMC | 199? | SEGA OziSoft Australia |
| Sega Mega Drive cart. | Marsupilami Model 051.060 | 1996 | Tec Toy Industria de Brinquedos S.A. Brazil |
| Sega Mega Drive cart. | Marsupilami Model 1841-50 | 1995 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Marsupilami Model FMAR05SMC | 199? | SEGA OziSoft Australia |
| Sega Mega Drive cart. | Marvel Land Model T-14093 | 1991 | NAMCOT Japan |
| Sega Mega Drive cart. | Master of Monsters Model T-63013 | 1991 | Toshiba EMI Japan |
| Sega Mega Drive cart. | Master of Weapon Model T-11063 | 1991 | Taito Corp. Japan |
| Sega Mega Drive cart. | Maten no Soumetsu Model T-46023 | 1993 | Hot-B Japan |
| Sega Mega Drive cart. | Mazin Saga Model G-4078 | 1993 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Mazin Wars Model 1069-50 | 1993 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | McDonald's Treasure Land Adventure Model G-4102 | 1993 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. |  Mega Bomberman 8-Player Demo | 1994 | Factor 5 |
| Sega Mega Drive cart. | Mega Bomberman Model 1573-50 | 1994 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Mega Booster Pak: Astérix and the Power of the Gods Model FAST07SMC | 199? | SEGA OziSoft Australia |
| Sega Mega Drive cart. | Mega Booster Pak: X-Men 2 - Clone Wars Model FXME03SMC | 199? | SEGA OziSoft Australia |
| Sega Mega Drive cart. | Mega Games 10 | 199? | Unknown |
| Sega Mega Drive cart. | Mega Games 2 | 1993 | SEGA Enterprises, Ltd. Tokyo, Japan |
