| Sega Mega Drive cart. |  Captain America and the Avengers | 1992 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. |  Captain Lang Model T-13103 | 1994 | Data East Corp. Japan |
| Sega Mega Drive cart. | Captain Planet and the Planeteers Model 042550 | 1993 | Tec Toy Industria de Brinquedos S.A. Brazil |
| Sega Mega Drive cart. | Captain Planet and the Planeteers Model 1031-40 | 1993 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Captain Planet and the Planeteers Model 1031-50 | 1993 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Castle of Illusion - Fushigi no Oshiro Daibouken Model G-4042 | 1990 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Castle of Illusion Estrelando Mickey Mouse Model 043060 | 1991 | Tec Toy Industria de Brinquedos S.A. Brazil |
| Sega Mega Drive cart. | Castlevania - The New Generation | 1994 | Konami Co., Ltd. Japan |
| Sega Mega Drive cart. | Chameleon Kid Model G-4070 | 1992 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Champions - World Class Soccer Model FCHA13SMC | 199? | SEGA OziSoft Australia |
| Sega Mega Drive cart. | Chao Ji Da Fu Weng | 199? | Gametech Japan |
| Sega Mega Drive cart. | Chaoji Majiang Club | 1995 | Creaton Softech, Inc. Taiwan |
| Sega Mega Drive cart. | Cheese Cat-Astrophe Starring Speedy Gonzales | 1995 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Chelnov Model T-13073 P | 1992 | Data East Corp. Japan |
| Sega Mega Drive cart. | Chess | 1998 | BSComp |
| Sega Mega Drive cart. | Chibi Maruko-chan - Wakuwaku Shopping | 1992 | NAMCOT Japan |
| Sega Mega Drive cart. | Chiki Chiki Boys Model 044250 P | 1992 | Tec Toy Industria de Brinquedos S.A. Brazil |
| Sega Mega Drive cart. | Chiki Chiki Boys Model 1075-50 P | 1992 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Chiki Chiki Boys Model G-4083 P | 1992 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Chou Kyuukai Miracle Nine | 1995 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Chou Touryuu Retsuden - Dino Land | 1991 | Wolf Team Japan |
| Sega Mega Drive cart. | Chuck Rock II - Son of Chuck Model T-115016-50 | 1993 | Core Design, Ltd. |
| Sega Mega Drive cart. | Chuck Rock II Model T-70063 | 1994 | Virgin Games, Ltd. UK 013715 |
| Sega Mega Drive cart. | Chuck Rock Model T-70036-50 | 1992 | Virgin Games, Ltd. UK 013715 |
| Sega Mega Drive cart. | Classic Collection Model 1199-50 | 1994 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Clay Fighter | 1994 | Interplay |
| Sega Mega Drive cart. | Cliffhanger | 1993 | Sony Imagesoft |
| Sega Mega Drive cart. | College Football's National Championship | 1994 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Columns III - Taiketsu! Columns World Model G-4108 | 1993 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Columns Model 1701-50 | 1990 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Columns Model G-4035 P | 1990 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Combat Cars Model T-119106-50 | 1994 | Accolade, Inc. San Jose, CA, USA 15605 |
| Sega Mega Drive cart. | Comix Zone Model 046.780 | 1995 | Tec Toy Industria de Brinquedos S.A. Brazil |
| Sega Mega Drive cart. | Comix Zone Model 1569-50 | 1995 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Comix Zone Model G-4132 | 1995 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Command & Conquer | 199? | Unknown |
| Sega Mega Drive cart. | Congo | 199? | Unknown |
| Sega Mega Drive cart. | Contra - The Hard Corps Model T-95093 | 1994 | Konami Co., Ltd. Japan |
| Sega Mega Drive cart. | Cool Spot Model T-70196-50 | 1994 | Virgin Games, Ltd. UK 013715 |
| Sega Mega Drive cart. | Corporation | 1992 | Virgin Games, Ltd. UK 013715 |
