| Sega Mega Drive cart. |  Cosmic Spacehead | 1993 | Codemasters Soft. Co., Ltd., The 015026 |
| Sega Mega Drive cart. |  Crack Down | 1991 | Tec Toy Industria de Brinquedos S.A. Brazil |
| Sega Mega Drive cart. | Crack Down Model 1111-50 | 1990 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Crack Down Model G-4024 | 1990 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Crayon Shin-chan - Arashi o Yobu Enji Model T-16033 | 1994 | Ma-Ba |
| Sega Mega Drive cart. | Crude Buster Model T-13063 | 1992 | Data East Corp. Japan |
| Sega Mega Drive cart. | Crüe Ball Model EM20005 | 1993 | Electronic Arts Victor, Inc. Japan |
| Sega Mega Drive cart. | Crying - Aseimei Sensou Model G-4087 | 1992 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. |  Crying Dragon | 1991 | TRECO |
| Sega Mega Drive cart. | Curse Model T-22013 | 1989 | Micronet Co., Ltd. Japan |
| Sega Mega Drive cart. | Cutie Suzuki no Ringside Angel Model T-20033 | 1990 | Asmik Co., Ltd. Japan |
| Sega Mega Drive cart. | CutThroat Island | 1995 | Acclaim Ent., Inc. Glen Cove, NY, USA |
| Sega Mega Drive cart. | Cyber Police ESWAT Model G-4029 | 1990 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | CyberBall - Football in the 21st Century Model G-4027 | 1990 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Daffy Duck in Hollywood Model 1094-50 | 1994 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Daffy Duck in Hollywood Model FDAF00SMC | 199? | SEGA OziSoft Australia |
| Sega Mega Drive cart. | Dahna - Megami Tanjou Model T-64013 | 1991 | IGS Corp. Information Global Service |
| Sega Mega Drive cart. | Dai Senpuu Model G-4034 P | 1990 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Daikoukai Jidai II Model T-76163 | 1994 | KOEI Co., Ltd. Japan |
| Sega Mega Drive cart. | Daikoukai Jidai Model T-76053 | 1992 | KOEI Co., Ltd. Japan |
| Sega Mega Drive cart. | Daimakaimura Model G-4013 P | 1989 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Dangerous Seed Model T-14033 P | 1990 | NAMCOT Japan |
| Sega Mega Drive cart. | Darius II Model T-11083 P | 1990 | Taito Corp. Japan |
| Sega Mega Drive cart. | Darkwing Duck | 199? | Unknown Russia |
| Sega Mega Drive cart. | Darwin 4081 Model G-4033 | 1990 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Dashin' Desperadoes | 1993 | Data East Corp. Japan |
| Sega Mega Drive cart. | David Robinson Basketball | 1992 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | David Robinson's Supreme Court | 1992 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Davis Cup World Tour | 1993 | Tengen, Inc. Milpilas, CA, USA |
| Sega Mega Drive cart. | Davis Cup World Tour Tennis 2 | 199? | Unknown |
| Sega Mega Drive cart. | Daze Before Christmas Model T-15156-50 | 1994 | SUNSOFT Kounan, Japan |
| Sega Mega Drive cart. | DecapAttack | 1991 | Tec Toy Industria de Brinquedos S.A. Brazil |
| Sega Mega Drive cart. | DecapAttack Model 1027-50 | 1991 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Deer Hunter | 199? | Tomsoft |
| Sega Mega Drive cart. | Demolition Man Model 046.970 | 1995 | Tec Toy Industria de Brinquedos S.A. Brazil |
| Sega Mega Drive cart. | Demolition Man Model T-81486-50 | 1995 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Desert Demolition Model FDES05SMC | 199? | SEGA OziSoft Australia |
| Sega Mega Drive cart. | Desert Strike - Return to the Gulf Model E224SMXI | 1993 | Electronic Arts CA, USA 14633 |
| Sega Mega Drive cart. |  Desert Strike - Return to the Gulf Model EAX02401038I | 1996 | Electronic Arts CA, USA 14633 |
| Sega Mega Drive cart. | Desert Strike - Return to the Gulf Model EM20010 | 1993 | Electronic Arts Victor, Inc. Japan |
