| Sega Mega Drive cart. |  Dragon Slayer - Eiyuu Densetsu II Model G-5544 | 1995 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Dragon Slayer - Eiyuu Densetsu Model G-5536 | 1994 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Dragon's Eye Plus - Shanghai III | 1991 | Home Data Japan |
| Sega Mega Drive cart. | Dragon's Revenge Model T-48143 | 1993 | Tengen, Inc. Milpilas, CA, USA |
| Sega Mega Drive cart. | Du Shen Zhi Meng Huan Puke | 1995 | Creaton Softech, Inc. Taiwan |
| Sega Mega Drive cart. | Duke Nukem 3D Model 052050 | 1997 | Tec Toy Industria de Brinquedos S.A. Brazil |
| Sega Mega Drive cart. |  Dune II - Battle for Arrakis Model T-70246-50 | 1993 | Virgin Interactive Ent., Ltd. UK 013715 |
| Sega Mega Drive cart. | Dune II - Kampf um den Wustenplaneten | 1993 | Virgin Interactive Ent., Ltd. UK 013715 |
| Sega Mega Drive cart. | Dyna Brothers 2 Model T-68063 | 1993 | CRI CSK Research Institute Japan |
| Sega Mega Drive cart. | Dyna Brothers Model T-68033 | 1992 | CRI CSK Research Institute Japan |
| Sega Mega Drive cart. | Dynamite Duke Model G-4038 | 1990 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Dynamite Headdy Model 046520 | 1994 | Tec Toy Industria de Brinquedos S.A. Brazil |
| Sega Mega Drive cart. | Dynamite Headdy Model 1543-50 | 1994 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Dynamite Headdy Model G-4117 | 1994 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Dyno Blaze | 199? | Unknown |
| Sega Mega Drive cart. | E-SWAT | 1990 | Tec Toy Industria de Brinquedos S.A. Brazil |
| Sega Mega Drive cart. | EA Hockey Model E187SMX | 1991 | Electronic Arts CA, USA 14633 |
| Sega Mega Drive cart. | EA Hockey Model EM20002 | 1992 | Electronic Arts Victor, Inc. Japan |
| Sega Mega Drive cart. | EA Sports Double Header Model E187SMXI | 1993 | EA Sports |
| Sega Mega Drive cart. | Earthworm Jim 2 Model T-70446-50 | 1995 | Virgin Interactive Ent., Ltd. UK 013715 |
| Sega Mega Drive cart. | Earthworm Jim Model 047080 | 1994 | Tec Toy Industria de Brinquedos S.A. Brazil |
| Sega Mega Drive cart. | Earthworm Jim Model T-70386-50 | 1994 | Virgin Interactive Ent., Ltd. UK 013715 |
| Sega Mega Drive cart. | Ecco - The Tides of Time Model 046470 | 1994 | Tec Toy Industria de Brinquedos S.A. Brazil |
| Sega Mega Drive cart. | Ecco - The Tides of Time Model 1553-50 | 1994 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Ecco Jr. Model FECC0035MC | 1995 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Ecco the Dolphin II Model G-4123 | 1994 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Ecco the Dolphin Asian Version | 1993 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Ecco the Dolphin Model 044360 | 1993 | Tec Toy Industria de Brinquedos S.A. Brazil |
| Sega Mega Drive cart. | Ecco the Dolphin Model 1042-50 | 1992 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Ecco the Dolphin Model FDOL00SMC | 1996 | SEGA OziSoft Australia |
| Sega Mega Drive cart. | Ecco the Dolphin Model G-4106 | 1993 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | El Viento Model T-32063 | 1991 | Wolf Team Japan |
| Sega Mega Drive cart. | Elemental Master Model T-18043 | 1990 | Tecno Soft. TechnoSoft Japan |
| Sega Mega Drive cart. | Eliminate Down Model T-73033 | 1993 | Soft Vision Japan |
| Sega Mega Drive cart. | Elitserien 95 | 1994 | Electronic Arts CA, USA 14633 |
| Sega Mega Drive cart. | Elitserien 96 | 1995 | Electronic Arts CA, USA 14633 |
| Sega Mega Drive cart. | Empire of Steel | 1992 | Flying Edge |
| Sega Mega Drive cart. | Escape from Mars Starring Taz | 1994 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | ESWAT - City Under Siege | 1990 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Eternal Champions Model 047010 | 1993 | Tec Toy Industria de Brinquedos S.A. Brazil |
