| Sega Mega Drive cart. |  Flink | 1994 | Sony Imagesoft |
| Sega Mega Drive cart. | Flux | 1995 | Unknown |
| Sega Mega Drive cart. | Flying Shark P | 1992 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Foreman for Real | 1995 | Acclaim Ent., Inc. Glen Cove, NY, USA |
| Sega Mega Drive cart. |  Forgotten Worlds P | 1990 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Forgotten Worlds P | 1990 | Tec Toy Industria de Brinquedos S.A. Brazil |
| Sega Mega Drive cart. | Forgotten Worlds Model G-4016 P | 1989 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Forsazh 5 Bystraya | 199? | Unknown |
| Sega Mega Drive cart. | From TV Animation Slam Dunk - Kyougou Makkou Taiketsu! Model T-133023 | 1995 | Bandai Co., Ltd. Japan |
| Sega Mega Drive cart. | Fun'n Games | 1993 | Sony Imagesoft |
| Sega Mega Drive cart. | Fushigi no Umi no Nadia Model T-14083 | 1991 | NAMCOT Japan |
| Sega Mega Drive cart. | FZ Senki Axis Model T-32013 | 1990 | Wolf Team Japan |
| Sega Mega Drive cart. | G-LOC Air Battle Model G-4079 | 1993 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Gaiares Model T-49013 | 1990 | Telenet Japan |
| Sega Mega Drive cart. | Gain Ground | 1991 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Gain Ground Model G-4036 P | 1991 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Galahad Model 044340 | 1992 | Tec Toy Industria de Brinquedos S.A. Brazil |
| Sega Mega Drive cart. | Galaxy Force II P | 1991 | Tec Toy Industria de Brinquedos S.A. Brazil |
| Sega Mega Drive cart. | Galaxy Force II Model 1133-50 P | 1992 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Galaxy Force II Model T-68013 P | 1991 | CRI CSK Research Institute Japan |
| Sega Mega Drive cart. | Gambler Jikochuushinha - Katayama Masayuki no Mahjong Doujou | 1990 | Game Arts Co., Ltd. Japan |
| Sega Mega Drive cart. | Game no Kanzume Otokuyou | 1995 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Garou Densetsu - Shukumei no Tatakai Model G-4100 | 1993 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Garou Densetsu 2 - Arata-Naru Tatakai Model T-146023 | 1994 | Takara Co., Ltd. Japan |
| Sega Mega Drive cart. | Gauntlet IV Model T-48216-50 | 1993 | Tengen, Inc. Milpilas, CA, USA |
| Sega Mega Drive cart. | Gauntlet Model T-48123 | 1993 | Tengen, Inc. Milpilas, CA, USA |
| Sega Mega Drive cart. | GEMS v2.8 | 199? | Unknown |
| Sega Mega Drive cart. | General Chaos Daikonsen Model EM20025 | 1994 | Electronic Arts CA, USA 14633 |
| Sega Mega Drive cart. | George Foreman's KO Boxing Model T-81116-50 | 1992 | Flying Edge |
| Sega Mega Drive cart. | Ghostbusters Model G-4030 | 1990 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Ghouls'n Ghosts | 1990 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Ghouls'n Ghosts | 1990 | Tec Toy Industria de Brinquedos S.A. Brazil |
| Sega Mega Drive cart. | GleyLancer Model T-25123 | 1992 | NCS Corp. Nippon Computer Systems Japan |
| Sega Mega Drive cart. | Go Net | 1992 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Gods Model T-119036 | 1993 | Accolade, Inc. San Jose, CA, USA 15605 |
| Sega Mega Drive cart. | Gods Model T-85013 | 1993 | PCM Complete |
| Sega Mega Drive cart. | Gold Collection: Sonic 2 Model FSON01SMC | 1994 | SEGA OziSoft Australia |
| Sega Mega Drive cart. | Golden Axe | 1990 | SEGA Enterprises, Ltd. Tokyo, Japan |
| Sega Mega Drive cart. | Golden Axe | 1990 | Tec Toy Industria de Brinquedos S.A. Brazil |
| Sega Mega Drive cart. | Golden Axe II | 1991 | Tec Toy Industria de Brinquedos S.A. Brazil |
