| Sega Genesis cart. |  Dark Castle Model 7034 | 1991 | Electronic Arts CA, USA 14633 |
| Sega Genesis cart. | Dashin' Desperadoes Model T-13066 | 1993 | Data East USA, Inc. |
| Sega Genesis cart. | David Crane's Amazing Tennis Model T-86036 | 1992 | Absolute Ent., Inc. Midland Park, NJ, USA |
| Sega Genesis cart. |  Davis Cup II | 199? | Unknown |
| Sega Genesis cart. | Deadly Moves Model T-33046 | 1992 | Kaneko USA, Ltd. IL, USA |
| Sega Genesis cart. | Death Duel Model T-56036 | 1992 | Razorsoft, Inc. Oklahoma City, OK, USA |
| Sega Genesis cart. | Debtor Hb | 2020 | PSCD Games |
| Sega Genesis cart. |  Debtor demo 4 | 2020 | PSCD Games |
| Sega Genesis cart. |  DecapAttack Model 1027 | 1991 | SEGA of America, Inc. San Francisco, CA, USA |
| Sega Genesis cart. | Demolition Man Model T-81486 | 1995 | Acclaim Ent., Inc. Glen Cove, NY, USA |
| Sega Genesis cart. | Demons of Asteborg Hb | 2019 | Neofid Studios |
| Sega Genesis cart. | Demons of Asteborg demo | 2019 | Neofid Studios |
| Sega Genesis cart. | Desert Demolition Model 1062 | 1994 | SEGA of America, Inc. San Francisco, CA, USA |
| Sega Genesis cart. | Desert Strike - Return to the Gulf Model 7022 | 1992 | Electronic Arts CA, USA 14633 |
| Sega Genesis cart. | Devilish - The Next Possession Model T-47066 | 1992 | Sage's Creation, Inc. |
| Sega Genesis cart. | Dick Tracy Model 1014 | 1991 | SEGA of America, Inc. San Francisco, CA, USA |
| Sega Genesis cart. | Dick Vitale's Awesome, Baby! College Hoops Model T-48236 | 1994 | Time Warner Interactive |
| Sega Genesis cart. | Dino Land Model T-49076 | 1991 | Renovation Products USA |
| Sega Genesis cart. | Disney's Aladdin Model 1058 | 1993 | SEGA of America, Inc. San Francisco, CA, USA |
| Sega Genesis cart. | Disney's Ariel the Little Mermaid Model 1041 | 1992 | SEGA of America, Inc. San Francisco, CA, USA |
| Sega Genesis cart. | Disney's Beauty and the Beast - Belle's Quest Model T-15106 | 1993 | SUNSOFT Kounan, Japan |
| Sega Genesis cart. | Disney's Beauty and the Beast - Roar of the Beast Model T-15116 | 1993 | SUNSOFT Kounan, Japan |
| Sega Genesis cart. | Disney's TaleSpin Model 1034 | 1992 | SEGA of America, Inc. San Francisco, CA, USA |
| Sega Genesis cart. | Disney's The Jungle Book Model T-70176 | 1994 | Virgin Interactive Ent., Inc. USA 52145 |
| Sega Genesis cart. | Disney's Toy Story Model T-239046 | 1996 | Disney Interactive |
| Sega Genesis cart. | DJ Boy Model 33016 | 1990 | Kaneko USA, Ltd. IL, USA |
| Sega Genesis cart. | Dominus | 199? | ASCII Ent. Soft., Inc. USA |
| Sega Genesis cart. | Doom Troopers - The Mutant Chronicles Model 6710 | 1995 | Playmates Interactive Ent., Inc. La Mirada, CA, USA |
| Sega Genesis cart. | Double Dragon | 1993 | Ballistic |
| Sega Genesis cart. | Double Dragon 3 - The Arcade Game Model T-81166 | 1992 | Flying Edge |
| Sega Genesis cart. | Double Dragon V - The Shadow Falls Model T-97106 | 1994 | Tradewest, Inc. Corsicana, TX, USA |
| Sega Genesis cart. | Double Dribble - The Playoff Edition Model T-95126 | 1994 | Konami Co., Ltd. Japan |
| Sega Genesis cart. | Dr. Robotnik's Mean Bean Machine Model 1706 | 1993 | SEGA of America, Inc. San Francisco, CA, USA |
| Sega Genesis cart. | Dragon - The Bruce Lee Story Model T-81496 | 1994 | Acclaim Ent., Inc. Glen Cove, NY, USA |
| Sega Genesis cart. | Dragon's Fury Model 301034-0150 | 1992 | Tengen, Inc. Milpilas, CA, USA |
| Sega Genesis cart. | Dragon's Lair | 199? | Taito Corp. Japan |
| Sega Genesis cart. |  Duke Nukem 3D | 2016 | Piko Interactive LLC |
| Sega Genesis cart. | Dune - The Battle for Arrakis Model T-70246 | 1993 | Virgin Interactive Ent., Inc. USA 52145 |
| Sega Genesis cart. | Dungeons & Dragons: Warriors of the Eternal Sun | 1992 | SEGA of America, Inc. San Francisco, CA, USA |
| Sega Genesis cart. | Dynamite Headdy Model 1543 | 1994 | SEGA of America, Inc. San Francisco, CA, USA |
