| IBM PC 5.25in. disk |  Rockford | 1987 | Mastertronic, Ltd. UK 012967 |
| IBM PC 5.25in. disk | Roger Zelazny: Nine Princes in Amber Model AMB-IB-D1 | 1985 | Telarium Corp. |
| IBM PC 5.25in. disk | Rogue | 1985 | Lane, Jon |
| IBM PC 5.25in. disk | Rogue | 1986 | Epyx, Inc. Redwood City, CA, USA |
| IBM PC 5.25in. disk | Rogue | 1983 | Artificial Intelligence Design Systems |
| IBM PC 5.25in. disk | Rollo and the Brush Brothers | 1983 | Windmill Soft. |
| IBM PC 5.25in. disk | S.D.I. - Strategic Defence Initiative Model 85323 | 1987 | Cinemaware Corp. |
| IBM PC 5.25in. disk | Saboteur II - Avenging Angel | 1987 | Keypunch Soft. |
| IBM PC 5.25in. disk | Santa Paravia | 1989 | Keypunch Soft. |
| IBM PC 5.25in. disk | Sarakon | 1991 | Starbyte Soft. |
| IBM PC 5.25in. disk | Satan | 1990 | Dinamic Soft. Madrid, Spain |
| IBM PC 5.25in. disk | Savage | 1989 | Probe Soft. |
| IBM PC 5.25in. disk | Science Fiction Classics Model IT4-IB1 | 198? | Infocom, Inc. MA, USA 51051 |
| IBM PC 5.25in. disk | Sea Dragon Model 132-0146 | 1983 | Adventure International |
| IBM PC 5.25in. disk | Seastalker Model IA2-IB1 | 1984 | Infocom, Inc. MA, USA 51051 |
| IBM PC 5.25in. disk |  Seastalker Model IA2-IB2 | 198? | Infocom, Inc. MA, USA 51051 |
| IBM PC 5.25in. disk | Second Front - Germany Turns East | 1990 | SSI Strategic Simulations, Inc. 16685 |
| IBM PC 5.25in. disk | Serpentine | 1984 | Broderbund Soft., Inc. CA, USA 47956 |
| IBM PC 5.25in. disk | Serve & Volley Model 68103 | 1988 | Accolade, Inc. San Jose, CA, USA 15605 |
| IBM PC 5.25in. disk | Set the Hostages Free | 1981 | TexaSoft |
| IBM PC 5.25in. disk | Seven Cities of Gold Model 1064 | 1985 | Electronic Arts CA, USA 14633 |
| IBM PC 5.25in. disk | Sex Vixens from Space | 1989 | Free Spirit Soft. |
| IBM PC 5.25in. disk | Shadowgate Model 85346 | 1987 | Mindscape, Inc. Northbrook, IL, USA 24294 |
| IBM PC 5.25in. disk | Shamus | 1984 | SynSoft |
| IBM PC 5.25in. disk | Shard of Spring P | 1987 | SSI Strategic Simulations, Inc. 16685 |
| IBM PC 5.25in. disk | Sherlock - The Riddle of the Crown Jewels Model CS1-IB3 | 1988 | Infocom, Inc. MA, USA 51051 |
| IBM PC 5.25in. disk | Shiloh - Grant's Trial in the West | 1987 | SSI Strategic Simulations, Inc. 16685 |
| IBM PC 5.25in. disk | Shufflepuck Cafe Model 13310 | 1989 | Broderbund Soft., Inc. CA, USA 47956 |
| IBM PC 5.25in. disk | Sid Meier's Pirates! | 1987 | MicroProse, Ltd. Bristol, UK 015352 |
| IBM PC 5.25in. disk | SideWinder | 1988 | Arcadia Systems, Inc. Mastertronic Group Costa Mesa, CA, USA |
| IBM PC 5.25in. disk | Sierra Championship Boxing Model 31700 | 1985 | Sierra On-Line, Inc. USA 20626 |
| IBM PC 5.25in. disk |  Sierra Demo | 1987 | Sierra On-Line, Inc. USA 20626 |
| IBM PC 5.25in. disk | Silent Service - The Submarine Simulation | 1985 | MicroProse, Ltd. Bristol, UK 015352 |
| IBM PC 5.25in. disk | Silicon Dreams Model 006671 | 1986 | Rainbird Soft. UK 012439 |
| IBM PC 5.25in. disk |  Silicon Dreams Model 46409 | 1988 | Firebird Licensees, Inc. USA 88777 |
| IBM PC 5.25in. disk | Sim City Model 001935 | 1989 | Infogrames Interactive, Inc. 329720 |
| IBM PC 5.25in. disk | SimCity Graphics Set 1 - Ancient Cities | 1990 | Maxis Soft. Moraga, CA, USA |
| IBM PC 5.25in. disk | SimCity Graphics Set 2 - Future Cities | 1991 | Maxis Soft. Moraga, CA, USA |
| IBM PC 5.25in. disk | Sinbad and the Throne of the Falcon Model 85353 | 1989 | Cinemaware Corp. |
| IBM PC 5.25in. disk | Skate or Die Model 1694 | 1988 | Electronic Arts CA, USA 14633 |
