| IBM PC 5.25in. disk |  Ski or Die Model 3455 | 1990 | Electronic Arts CA, USA 14633 |
| IBM PC 5.25in. disk | Skweek | 1989 | Loriciels France |
| IBM PC 5.25in. disk | Skyfox II Model 1509 | 1988 | Electronic Arts CA, USA 14633 |
| IBM PC 5.25in. disk | Softside April DV #40 | 1983 | SoftSide Publications, Inc. |
| IBM PC 5.25in. disk | Softside February DV #38 | 1983 | SoftSide Publications, Inc. |
| IBM PC 5.25in. disk | Softside January DV #37 | 1983 | SoftSide Publications, Inc. |
| IBM PC 5.25in. disk | Softside July DV #43 | 1983 | SoftSide Publications, Inc. |
| IBM PC 5.25in. disk | Softside June DV #42 | 1983 | SoftSide Publications, Inc. |
| IBM PC 5.25in. disk | Softside March DV #39 | 1983 | SoftSide Publications, Inc. |
| IBM PC 5.25in. disk | Softside May DV #41 | 1983 | SoftSide Publications, Inc. |
| IBM PC 5.25in. disk | Soko-Ban | 1984 | Spectrum HoloByte |
| IBM PC 5.25in. disk | Solo Flight | 1983 | MicroProse, Ltd. Bristol, UK 015352 |
| IBM PC 5.25in. disk | Sons of Liberty P | 1988 | SSI Strategic Simulations, Inc. 16685 |
| IBM PC 5.25in. disk | Sorcerer Model IZ5-IB1 | 1984 | Infocom, Inc. MA, USA 51051 |
| IBM PC 5.25in. disk |  Sorcerer Model IZ5-IB2 | 1986 | Infocom, Inc. MA, USA 51051 |
| IBM PC 5.25in. disk | Space 1889 | 1990 | Paragon Soft. |
| IBM PC 5.25in. disk | Space Battles | 1986 | Keypunch Soft. |
| IBM PC 5.25in. disk | Space Commanders | 1983 | Columbia Data Products |
| IBM PC 5.25in. disk | Space MAX | 1992 | Starbyte Soft. |
| IBM PC 5.25in. disk | Space Quest II - Vohaul's Revenge | 1988 | Sierra On-Line, Inc. USA 20626 |
| IBM PC 5.25in. disk | Space Strike | 1982 | Funtastic |
| IBM PC 5.25in. disk | Special Maxell Edition of PGA Tour Golf | 1990 | Electronic Arts CA, USA 14633 |
| IBM PC 5.25in. disk | Speedball 2 - Brutal Deluxe | 1990 | Image Works |
| IBM PC 5.25in. disk | Spellbreaker Model IZ6-IB2 | 1985 | Infocom, Inc. MA, USA 51051 |
| IBM PC 5.25in. disk | Spellcasting 301 - Spring Break | 1992 | Legend Ent. Co. Chantilly, VA, USA |
| IBM PC 5.25in. disk | Spiderbot | 1988 | Epyx, Inc. Redwood City, CA, USA |
| IBM PC 5.25in. disk | Spitfire '40 Model 49554 | 1988 | Microcomputer Games |
| IBM PC 5.25in. disk | Spitfire Ace | 1984 | MicroProse, Ltd. Bristol, UK 015352 |
| IBM PC 5.25in. disk | Sports Collection 19: Pro Tennis Tour | 1990 | Hit Squad, The UK 13156 |
| IBM PC 5.25in. disk | Spot | 1991 | Virgin Games, Ltd. UK 013715 |
| IBM PC 5.25in. disk | Spyhunter | 1984 | Bally Midway Mfg. Co. Franklin Park, IL, USA |
| IBM PC 5.25in. disk | Squirm | 1982 | TexaSoft |
| IBM PC 5.25in. disk |  Star Control Model 005011 | 1990 | Accolade Europe, Ltd. London, England 020622 |
| IBM PC 5.25in. disk | Star Goose! | 1989 | Logotron, Ltd. |
| IBM PC 5.25in. disk | Star Pack | 1992 | Prism Leisure Corp. plc UK 014293 |
| IBM PC 5.25in. disk | Star Saga: One - Beyond the Boundary | 1988 | MasterPlay Publishing Corp. 39853 |
| IBM PC 5.25in. disk | Star Saga: Two - The Clathran Menace | 1989 | MasterPlay Publishing Corp. 39853 |
| IBM PC 5.25in. disk | Star Trek V - The Final Frontier | 1989 | Mindscape, Inc. Northbrook, IL, USA 24294 |
| IBM PC 5.25in. disk | Starbyte Super Soccer | 1991 | Starbyte Soft. |
| IBM PC 5.25in. disk | Starcross Model IS1-IB1 | 1982 | Infocom, Inc. MA, USA 51051 |
