| IBM PC 5.25in. disk |  Donkey Kong Model DX5508 | 1983 | Atarisoft Atari, Inc. |
| IBM PC 5.25in. disk | Double Dragon | 1988 | Arcadia Systems, Inc. Mastertronic Group Costa Mesa, CA, USA |
| IBM PC 5.25in. disk | Double Dragon II - The Revenge | 1989 | Virgin Mastertronic, Ltd. UK |
| IBM PC 5.25in. disk | Downhill Challenge Model 14010 | 1989 | Broderbund Soft., Inc. CA, USA 47956 |
| IBM PC 5.25in. disk | Dr. Ruth's Computer Game of Good Sex Model 45854 | 1986 | Microcomputer Games |
| IBM PC 5.25in. disk | Drakkhen | 1990 | Infogrames Interactive, Inc. 329720 |
| IBM PC 5.25in. disk | Draw Poker Model 41654 | 1983 | Microcomputer Games |
| IBM PC 5.25in. disk | Dream Team Fantasy Football | 1989 | MBI Soft. |
| IBM PC 5.25in. disk | Dream Warrior | 1989 | Keypunch Soft. |
| IBM PC 5.25in. disk | Dungeon Master | 1992 | FTL Faster Than Light |
| IBM PC 5.25in. disk | Dungeon of Pun III | 1991 | Gemini Marketing, Ltd. |
| IBM PC 5.25in. disk | Dunjonquest: The Temple of Apshai Model 215D | 1980 | Automated Simulations, Inc. |
| IBM PC 5.25in. disk | Earl Weaver Baseball II Model 4404 | 1991 | Electronic Arts CA, USA 14633 |
| IBM PC 5.25in. disk | Earl Weaver Baseball Ver.1.5 Model 3028 | 1989 | Electronic Arts CA, USA 14633 |
| IBM PC 5.25in. disk | Earl Weaver Baseball Model 1449 | 1988 | Electronic Arts CA, USA 14633 |
| IBM PC 5.25in. disk | Earthly Delights | 1986 | Unknown |
| IBM PC 5.25in. disk | East vs. West Berlin 1948 | 1990 | Time Warp |
| IBM PC 5.25in. disk | Echecs 3D | 1986 | FIL France Image Logiciel |
| IBM PC 5.25in. disk | Electric Crayon ABC's Model MERIT0004 | 1990 | Merit Soft. |
| IBM PC 5.25in. disk | Electronic Grammar - Parts of Speech | 1986 | IBM Corp. International Business Machines |
| IBM PC 5.25in. disk | Elementary School 3 | 198? | Compton's NewMedia |
| IBM PC 5.25in. disk | Elite Model 002994 | 1987 | Firebird Soft. UK 012439 |
| IBM PC 5.25in. disk |  Elite Model 46328 | 198? | Firebird Licensees, Inc. USA 88777 |
| IBM PC 5.25in. disk | Emmanuelle - A Game of Eroticism | 1989 | Tomahawk |
| IBM PC 5.25in. disk | Emmanuelle - A Game of Eroticism | 1989 | System 4 de Espana, S.A. Spain |
| IBM PC 5.25in. disk | Empire - Wargame of the Century | 1988 | Interstel |
| IBM PC 5.25in. disk | Enchanter Trilogy Model IT2-IB2 | 198? | Infocom, Inc. MA, USA 51051 |
| IBM PC 5.25in. disk | Enchanter Model IZ4-IB1 | 1983 | Infocom, Inc. MA, USA 51051 |
| IBM PC 5.25in. disk | Enchanter Model IZ4-IB2 | 198? | Infocom, Inc. MA, USA 51051 |
| IBM PC 5.25in. disk | Epidemic! P | 1983 | SSI Strategic Simulations, Inc. 16685 |
| IBM PC 5.25in. disk | Erle Stanley Gardner: Perry Mason - The Case of the Mandarin Murder Model PMS-IB-D1 | 1985 | Telarium Corp. |
| IBM PC 5.25in. disk | Escape To Vegas Model DSCNT0004 | 198? | Disk-Count Soft., Inc. |
| IBM PC 5.25in. disk | European Nations & Locations Model BRITT0015 | 198? | DesignWare |
| IBM PC 5.25in. disk | Executive Suite | 1982 | Armonk Corp. |
| IBM PC 5.25in. disk | Eye of Horus | 1989 | Logotron, Ltd. |
| IBM PC 5.25in. disk | F-15 Strike Eagle | 1985 | MicroProse, Ltd. Bristol, UK 015352 |
| IBM PC 5.25in. disk | F-15 Strike Eagle II | 1989 | MicroProse Soft., Inc. USA 19703 |
| IBM PC 5.25in. disk | F-16 Combat Pilot Model 5098 | 1989 | Electronic Arts CA, USA 14633 |
| IBM PC 5.25in. disk | F-29 Retaliator Model 015106 | 1990 | Ocean Soft., Ltd. 13156 |
| IBM PC 5.25in. disk | Facemaker | 1982 | Spinnaker Soft. Corp. |
